Early clinical outcomes of keratoplasty using donor corneas preserved in Sinasol (Zisol) versus Optisol-GS
Mohamad Javad Babaki 1 , Kiana Hassanpour1 , Mozhgan Rezaei Kanavi2 *
- Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: To compare early clinical outcomes of keratoplasty with the use of corneas preserved either in Sinasol (ZiSol) (made by TiamPharma, Tehran, Iran) or Optisol-GS media.
Methods: Fifty-two penetrating keratoplasty (PKP) using 20 donor corneas stored in Optisol-GS and 32 donor corneas stored in ZiSol were performed along with 29 Descemet stripping automated endothelial keratoplasty (DSAEK) using 23 Optisol-GS and 6 ZiSol-stored donor corneas by random assignment. Corrected distance visual acuity (CDVA) and corneal edema grade measurements were made at 1 week, 1 month, 3 months and 6 months post-keratoplasty. Microbial infection and suture related complications during 6 months post-keratoplasty and successful graft attachment at 6 months post-DSAEK were documented. Graft re-epithelialization time after PKP was estimated by the surgeons.
Results: No statistically significant differences in clinical outcomes of keratoplasty using corneas stored in the two media were found during 6 months after transplantation. Final CDVA was comparable in the ZiSol and Optisol-GS groups (0.52 logMAR post-PKP and 0.56 logMAR post-DSAEK in ZiSol group vs. 0.41 post-PKP and 0.63 logMAR pos-tDSAEK in Optisol-GS group, P=0.390 and P=0.679). Postoperative corneal edema grade between the two media groups were not different significantly and graft clarity was observed 92.1 % and 95.3% in ZiSol and Optisol-GS groups, respectively. Complete graft re-epithelialization time was reported 7 days after transplantation almost in the all cases of both groups and was not significantly different (96.9% and 100% in ZiSol and Optisol-GS groups, respectively, P>0.999). Although, microbial infection occurred in the two ZiSol-stored corneas (6.3%) post-PKP, but it failed to cause significant difference statistically (P=0.517). Suture related complications were similar in ZiSol and Optisol-GS groups (15.6% vs. 15%, respectively, P>0.999). Post-DSAEK successful graft complete attachment was observed in the 100% of ZiSol-stored corneas and 87% of Optisol-GS-stored corneas without significant difference (P>0.999).
Conclusion: The clinical outcomes of Keratoplasty were comparable at 6 months for donor corneas stored in ZiSol and Optisol-GS.
